Cardiac biophysical detailed synergetic modality rendering and visible correlation

Front Physiol. 2023 Apr 7:14:1086154. doi: 10.3389/fphys.2023.1086154. eCollection 2023.

Abstract

The heart is a vital organ in the human body. Research and treatment for the heart have made remarkable progress, and the functional mechanisms of the heart have been simulated and rendered through the construction of relevant models. The current methods for rendering cardiac functional mechanisms only consider one type of modality, which means they cannot show how different types of modality, such as physical and physiological, work together. To realistically represent the three-dimensional synergetic biological modality of the heart, this paper proposes a WebGL-based cardiac synergetic modality rendering framework to visualize the cardiac physical volume data and present synergetic correspondence rendering of the cardiac electrophysiological modality. By constructing the biological detailed interactive histogram, users can implement local details rendering for the heart, which could reveal the cardiac biology details more clearly. We also present cardiac physical-physiological correlation visualization to explore cardiac biological association characteristics. Experimental results show that the proposed framework can provide favorable cardiac biological detailed synergetic modality rendering results in terms of both effectiveness and efficiency. Compared with existing methods, the framework can facilitate the study of the internal mechanism of the heart and subsequently deduce the process of initiation, development, and transformation from a healthy heart to an ill one, and thereby improve the diagnosis and treatment of cardiac disorders.

Keywords: WebGL-based rendering; biophysical detail; cardiac synergetic configuration; interactive configuration histogram; physical and electrophysiological correlation.

Grants and funding

This work was supported by the Natural Science Foundation of Shandong Province No. ZR2019MF011 and ZR2021MF011. This work was also supported in part by the Natural Science Foundation of China No. 62277045 and 62076149.