Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation

R K Rigsby; P Brahmbhatt; A B Desai; G Bathla; B A Ebner; V Gupta; P Vibhute; A K Agarwal

doi:10.3174/ajnr.A7827

Newly Recognized CNS Tumors in the 2021 World Health Organization Classification: Imaging Overview with Histopathologic and Genetic Correlation

AJNR Am J Neuroradiol. 2023 Apr;44(4):367-380. doi: 10.3174/ajnr.A7827. Epub 2023 Mar 30.

Authors

R K Rigsby¹, P Brahmbhatt¹, A B Desai¹, G Bathla², B A Ebner³, V Gupta¹, P Vibhute¹, A K Agarwal⁴

Affiliations

¹ From the Department of Radiology (R.K.R., P.B., A.B.D., V.G., P.V., A.K.A.), Mayo Clinic, Jacksonville, Florida.
² Department of Radiology (G.B.), Mayo Clinic, Rochester, Minnesota.
³ Department of Laboratory Medicine and Pathology (B.A.E.), Mayo Clinic, Rochester, Minnesota.
⁴ From the Department of Radiology (R.K.R., P.B., A.B.D., V.G., P.V., A.K.A.), Mayo Clinic, Jacksonville, Florida Agarwal.Amit@mayo.edu.

Abstract

In 2021, the World Health Organization released an updated classification of CNS tumors. This update reflects the growing understanding of the importance of genetic alterations related to tumor pathogenesis, prognosis, and potential targeted treatments and introduces 22 newly recognized tumor types. Herein, we review these 22 newly recognized entities and emphasize their imaging appearance with correlation to histologic and genetic features.

Publication types

Review

MeSH terms

Central Nervous System Neoplasms* / diagnostic imaging
Central Nervous System Neoplasms* / genetics
Central Nervous System Neoplasms* / pathology
Diagnostic Imaging
Humans
Prognosis
World Health Organization