Perm1 Protects the Heart From Pressure Overload-Induced Dysfunction by Promoting Oxidative Metabolism

Circulation. 2023 Mar 14;147(11):916-919. doi: 10.1161/CIRCULATIONAHA.122.060173. Epub 2023 Mar 13.

Shizuko Tachibana¹, Nam-Kyung Yu², Ruixia Li^{1

3}, Carolina Fernandez-Costa², Alex Liang^{1

3}, Janet Choi¹, Dayoen Jung¹, Changchun Xiao⁴, Anastasia Kralli⁵, John R Yates 3rd², Robert S Ross^{1

3}, Yoshitake Cho^{1

3}

¹ Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla (S.T., R.L., A.L., J.C., D.J., R.S.R., Y.C.).
² Departments of Molecular Medicine and Neurobiology (N.-K.Y., C.F.-C., J.R.Y.), The Scripps Research Institute, La Jolla, CA.
³ Department of Medicine/Cardiology, Veterans Administration Healthcare, San Diego, CA (R.L., A.L., R.S.R., Y.C.).
⁴ Department of Immunology and Microbiology (C.X.), The Scripps Research Institute, La Jolla, CA.
⁵ Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD (A.K.).

No abstract available

Keywords: MICOS; Perm1; mitochondria; oxidative metabolism; pressure overload.

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