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1: Agents Actions. 1987 Aug;21(3-4):384-6.Links

Roles of kallikrein-kinin system in acute inflammation: studies on high- and low-molecular weight kininogens-deficient rats (B/N-Katholiek strain).

Oh-ishi S, Hayashi I, Utsunomiya I, Hayashi M, Yamaki K, Yamasu A, Nakano T.

Department of Pharmacology, School of Pharmac. Sci., Kitasato University, Minatoku, Tokyo.

Carrageenin-induced paw edema in HMW- and LMW-kininogens-deficient rats was significantly less than that in normal rats. There are three kininogens, HMW-, LMW- and T-kininogens, in normal rat plasma, but B/N-Katholiek rat plasma contains only T-kininogen. The pretreatment with captopril, a kiniase II inhibitor, enhanced paw swelling of normal rats, but not that of the deficient rats, indicating that bradykinin released from HMW-kininogen may have a role for the swelling but T-kinin may not be released in this inflammation.

PMID: 3687591 [PubMed - indexed for MEDLINE]

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