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Toxicol Lett. 1987 Dec;39(2-3):295-300.

Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals.

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  • Central Research and Development Department, E.I. du Pont de Nemours and Company, Haskell Laboratory for Toxicology and Industrial, Newark, DE 19714.


The weight of the mouse liver following feeding of ammonium perfluorooctanoate, ammonium perfluorononanoate, Telomer B ammonium sulfate, and WG-III was increased in a dose-dependent manner. Dietary levels of 3 ppm or greater ammonium perfluorooctanoate for either 14 or 21 days produced a significant elevation in liver weight both on an absolute and on an organ/body weight ratio basis. Similarly, ammonium perfluorononanoate produced significant increases at the lowest level tested, 3 ppm. Telomer B ammonium sulfate and WG-III also produced liver weight increases but at higher feeding levels. The striking increase in liver weight following relatively short-term exposures in mice makes this a useful screening test for comparing the liver-enlarging capacity of ammonium perfluorooctanoate and related fluorochemicals.

[PubMed - indexed for MEDLINE]
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