Mayo Clin Proc. 1987 Dec;62(12):1095-100.

Autosomal dominant familial Mediterranean fever-like syndrome with amyloidosis.

Gertz MA, Petitt RM, Perrault J, Kyle RA.

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Division of Hematology, Mayo Clinic, Rochester, MN 55905.

Abstract

We report a pedigree in which a syndrome that resembled familial Mediterranean fever occurred in four family members over three successive generations. All four patients had systemic amyloidosis. Typically, patients with familial Mediterranean fever show an autosomal recessive inheritance pattern. The disorder commonly afflicts Sephardic Jews, Arabs, and persons of Turkish descent. Colchicine therapy dramatically reduces the attack rate of serositis. The family described herein is unique because of their European ethnicity and the autosomal dominant inheritance pattern. Unlike typical familial Mediterranean fever, colchicine had no influence on the attacks and did not prevent amyloidosis in the three patients who received this treatment.

PMID:: 3682954; [PubMed - indexed for MEDLINE]

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Cited by 4 PubMed Central articles

The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers. [Am J Hum Genet. 2001]
The tumor-necrosis-factor receptor-associated periodic syndrome: new mutations in TNFRSF1A, ancestral origins, genotype-phenotype studies, and evidence for further genetic heterogeneity of periodic fevers.
Aksentijevich I, Galon J, Soares M, Mansfield E, Hull K, Oh HH, Goldbach-Mansky R, Dean J, Athreya B, Reginato AJ, et al. Am J Hum Genet. 2001 Aug; 69(2):301-14. Epub 2001 Jul 6.
Linkage of familial Hibernian fever to chromosome 12p13. [Am J Hum Genet. 1998]
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McDermott MF, Ogunkolade BW, McDermott EM, Jones LC, Wan Y, Quane KA, McCarthy J, Phelan M, Molloy MG, Powell RJ, et al. Am J Hum Genet. 1998 Jun; 62(6):1446-51.
Gene localization for an autosomal dominant familial periodic fever to 12p13. [Am J Hum Genet. 1998]
Gene localization for an autosomal dominant familial periodic fever to 12p13.
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