Non-invasive sensory neuromodulation in epilepsy: Updates and future perspectives

Zhongxia Li; Liying Chen; Cenglin Xu; Zhong Chen; Yi Wang

doi:10.1016/j.nbd.2023.106049

Non-invasive sensory neuromodulation in epilepsy: Updates and future perspectives

Neurobiol Dis. 2023 Apr:179:106049. doi: 10.1016/j.nbd.2023.106049. Epub 2023 Feb 20.

Authors

Zhongxia Li¹, Liying Chen², Cenglin Xu³, Zhong Chen³, Yi Wang⁴

Affiliations

¹ Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; Zhejiang Rehabilitation Medical Center Department, The Third Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
² Department of Pharmacy, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
³ Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
⁴ Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; Zhejiang Rehabilitation Medical Center Department, The Third Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: wang-yi@zju.edu.cn.

PMID: 36813206
DOI: 10.1016/j.nbd.2023.106049

Abstract

Epilepsy, one of the most common neurological disorders, often is not well controlled by current pharmacological and surgical treatments. Sensory neuromodulation, including multi-sensory stimulation, auditory stimulation, olfactory stimulation, is a kind of novel noninvasive mind-body intervention and receives continued attention as complementary safe treatment of epilepsy. In this review, we summarize the recent advances of sensory neuromodulation, including enriched environment therapy, music therapy, olfactory therapy, other mind-body interventions, for the treatment of epilepsy based on the evidence from both clinical and preclinical studies. We also discuss their possible anti-epileptic mechanisms on neural circuit level and propose perspectives on possible research directions for future studies.

Keywords: Epilepsy; Mind-body interventions; Neural circuit; Sensory neuromodulation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anticonvulsants
Epilepsy* / therapy
Humans
Transcranial Magnetic Stimulation

Substances

Anticonvulsants