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Hum Toxicol. 1987 Sep;6(5):395-6.

The spermicidal potency of Coca-Cola and Pepsi-Cola.

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  • 1Department of Medicine, Veterans General Hospital, Taipei, ROC.


The inhibitory effect of Old Coke, caffeine-free New Coke, New Coke, Diet Coke and Pepsi-Cola on human sperm motility was studied with a trans-membrane migration method. None of them could decrease sperm motility to less than 70% of control within one hour. A previous study which claimed a marked variation of spermicidal potencies among different formulations of Coca-Cola could not be confirmed. Even if cola has a spermicidal effect, its potency is relatively weak as compared with other well-known spermicidal agents.

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