Brain Res. 1987 Oct 27;424(2):311-9.

Tolerance to morphine microinjections in the periaqueductal gray (PAG) induces tolerance to systemic, but not intrathecal morphine.

Source

Department of Pharmacology, University of Illinois College of Medicine, Chicago 60612.

Abstract

The acquisition and retention of tolerance to the antinociceptive effect of supraspinal morphine on the tail withdrawal reflex was assessed in rats implanted with unilateral cannulae in the periaqueductal gray (PAG). Development of tolerance to daily microinjections of morphine was indicated by the return of the tail flick response within 4 days, followed by the recovery of analgesic sensitivity one week later. After tolerance had developed, the effect of an acute systemic (1.5-4.5 mg/kg) or intrathecal (5-15 micrograms) morphine injection was determined. 'Cross-tolerance' was observed between systemic and supraspinal morphine but not between intrathecal and supraspinal morphine. The data indicate that tolerance to chronic intracerebral morphine produces the same behavioral consequences as tolerance to systemic morphine.

PMID:: 3676830; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Morphine

Grant Support

DA02845/DA/NIDA NIH HHS/United States

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Elsevier Science

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MORPHINE - HSDB

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Cited by 8 PubMed Central articles

Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons. [J Pharmacol Exp Ther. 2010]
Tolerance to the antinociceptive effect of morphine in the absence of short-term presynaptic desensitization in rat periaqueductal gray neurons.
Fyfe LW, Cleary DR, Macey TA, Morgan MM, Ingram SL. J Pharmacol Exp Ther. 2010 Dec; 335(3):674-80. Epub 2010 Aug 25.
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Extracellular signal-regulated kinase 1/2 activation counteracts morphine tolerance in the periaqueductal gray of the rat.
Macey TA, Bobeck EN, Hegarty DM, Aicher SA, Ingram SL, Morgan MM. J Pharmacol Exp Ther. 2009 Nov; 331(2):412-8. Epub 2009 Aug 14.
Glutamate modulation of antinociception, but not tolerance, produced by morphine microinjection into the periaqueductal gray of the rat. [Brain Res. 2009]
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Morgan MM, Bobeck EN, Ingram SL. Brain Res. 2009 Oct 27; 1295:59-66. Epub 2009 Aug 5.

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