Nature. 1987 Nov 19-25;330(6145):221-6.

The structure of an oligo(dA).oligo(dT) tract and its biological implications.

Source

Medical Research Council Laboratory of Molecular Biology, Cambridge, UK.

Abstract

Poly(dA).poly(dT) has unusual properties in that it cannot associate into nucleosomes and short, phased runs of it cause DNA bending. The crystal structure of a B-type DNA dodecamer containing a homopolymeric run of six A.T base pairs shows that this region possesses special structural features, including a system of bifurcated hydrogen bonds, which explains some of the properties of this simple homopolymer.

PMID:: 3670410; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

The propeller DNA conformation of poly(dA).poly(dT). [Nucleic Acids Res. 1989]
The propeller DNA conformation of poly(dA).poly(dT).
Aymami J, Coll M, Frederick CA, Wang AH, Rich A. Nucleic Acids Res. 1989 Apr 25; 17(8):3229-45.
Structure of the hydration shells of oligo(dA-dT).oligo(dA-dT) and oligo(dA).oligo(dT) tracts in B-type conformation on the basis of Monte Carlo calculations. [Biopolymers. 1990]
Structure of the hydration shells of oligo(dA-dT).oligo(dA-dT) and oligo(dA).oligo(dT) tracts in B-type conformation on the basis of Monte Carlo calculations.
Eisenhaber F, Tumanyan VG, Abagyan RA. Biopolymers. 1990; 30(5-6):563-81.
Anomalous structure and properties of poly (dA).poly(dT). Computer simulation of the polynucleotide structure with the spine of hydration in the minor groove. [Nucleic Acids Res. 1987]
Anomalous structure and properties of poly (dA).poly(dT). Computer simulation of the polynucleotide structure with the spine of hydration in the minor groove.
Chuprina VP. Nucleic Acids Res. 1987 Jan 12; 15(1):293-311.
Review Helix geometry, hydration, and G.A mismatch in a B-DNA decamer. [Science. 1987]
Review Helix geometry, hydration, and G.A mismatch in a B-DNA decamer.
Privé GG, Heinemann U, Chandrasegaran S, Kan LS, Kopka ML, Dickerson RE. Science. 1987 Oct 23; 238(4826):498-504.
Review Poly(dA:dT) tracts: major determinants of nucleosome organization. [Curr Opin Struct Biol. 2009]
Review Poly(dA:dT) tracts: major determinants of nucleosome organization.
Segal E, Widom J. Curr Opin Struct Biol. 2009 Feb; 19(1):65-71. Epub 2009 Feb 7.

See reviews... See all...

Cited by over 100 PubMed Central articles

The transcription factor AmrZ utilizes multiple DNA binding modes to recognize activator and repressor sequences of Pseudomonas aeruginosa virulence genes. [PLoS Pathog. 2012]
The transcription factor AmrZ utilizes multiple DNA binding modes to recognize activator and repressor sequences of Pseudomonas aeruginosa virulence genes.
Pryor EE Jr, Waligora EA, Xu B, Dellos-Nolan S, Wozniak DJ, Hollis T. PLoS Pathog. 2012 Apr; 8(4):e1002648. Epub 2012 Apr 12.
Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism. [Int J Mol Sci. 2012]
Conformational Changes in DNA upon Ligand Binding Monitored by Circular Dichroism.
Chang YM, Chen CK, Hou MH. Int J Mol Sci. 2012; 13(3):3394-413. Epub 2012 Mar 12.
A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. [Mol Cancer. 2012]
A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line.
Souissi I, Ladam P, Cognet JA, Le Coquil S, Varin-Blank N, Baran-Marszak F, Metelev V, Fagard R. Mol Cancer. 2012 Mar 16; 11:12. Epub 2012 Mar 16.

See all...

Structures reported by this article

The Structure Of An Oligo(Da).Oligo(Dt) Tract And Its Biological Implications

PDB: 1D98

Source: synthetic construct

Method: X-Ray Diffraction

Resolution: 2.5 Å

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Structure
Three-dimensional structure records in the NCBI Structure database for data reported in the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The structure of an oligo(dA).oligo(dT) tract and its biological implications.
The structure of an oligo(dA).oligo(dT) tract and its biological implications.
Nature. 1987 Nov 19-25 ;330(6145):221-6.

PubMed
Assessment of depression in geriatric medical outpatients: the validity of two s...
Assessment of depression in geriatric medical outpatients: the validity of two screening measures.
J Am Geriatr Soc. 1987 Nov ;35(11):989-95.

PubMed
Estrone and estradiol concentrations in human ovaries, testes, and adrenals duri...
Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life.
J Clin Endocrinol Metab. 1987 Nov ;65(5):862-7.

PubMed
Recurrent depression: an assessment of family burden and family attitudes.
Recurrent depression: an assessment of family burden and family attitudes.
J Clin Psychiatry. 1987 Oct ;48(10):395-400.

PubMed
Posttraumatic phenomena in a longitudinal study of children following a natural ...
Posttraumatic phenomena in a longitudinal study of children following a natural disaster.
J Am Acad Child Adolesc Psychiatry. 1987 Sep ;26(5):764-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: