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J Invest Dermatol. 1987 Oct;89(4):426-9.

Effect of dimethylsulfoxide concentration on the permeability of neonatal rat stratum corneum to alkanols.

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  • 1School of Pharmacy, Robert Gordon's Institute of Technology, Aberdeen, Scotland, U.K.

Abstract

The effect of dimethylsulfoxide (DMSO) concentration on the permeability of neonatal rat stratum corneum to 14C labeled propan-1-ol and hexan-1-ol was studied in vitro. The permeability coefficients were determined from a range of DMSO-water systems. After soaking in water overnight, the same stratum corneum was used with water as both delivery and recipient phases for the alkanols. Concentrations below 70% DMSO reduced the penetration rate as a result of the solvent effect of DMSO and the formation of a DMSO-alkanol complex. Above 70% DMSO permeability increased, with a permeability coefficient greater than that from water being achieved at concentrations in excess of 80% DMSO. The second run, with water as delivery phase, showed that the effect was reversible below 70% DMSO, but that at higher concentrations DMSO had produced an irreversible change in the permeability of stratum corneum. We hypothesize a hydrogen bond-mediated mechanism for the increased permeability.

PMID:
3668285
[PubMed - indexed for MEDLINE]
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