Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. III--Synthesis and CNS activity of some 1-substituted derivatives of the novel heterocyclic system 4,5-dihydro-s-triazolo [3,4-d]-1,5-benzothiazepine

V Ambrogi; G Grandolini; C Rossi; M C Tiralti

Studies on annelated 1,4-benzothiazines and 1,5-benzothiazepines. III--Synthesis and CNS activity of some 1-substituted derivatives of the novel heterocyclic system 4,5-dihydro-s-triazolo [3,4-d]-1,5-benzothiazepine

Farmaco Sci. 1987 Aug;42(8):575-83.

Authors

V Ambrogi¹, G Grandolini, C Rossi, M C Tiralti

Affiliation

¹ Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università di Perugia, Italy.

PMID: 3666128

Abstract

A series of new 4,5-dihydro-s-triazolo [3,4-d]-1,5-benzothiazepines has been prepared. All the described compounds are representative of a novel ring system. Some of these compounds were tested for their CNS activity and effects comparable with the ones of diazepam were observed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anticonvulsants / chemical synthesis
Central Nervous System Depressants / chemical synthesis*
Chemical Phenomena
Chemistry
Drug Interactions
Hexobarbital / pharmacology
Lethal Dose 50
Male
Mice
Motor Activity / drug effects
Pentylenetetrazole / antagonists & inhibitors
Sleep / drug effects
Thiazepines / chemical synthesis*
Thiazepines / pharmacology
Thiazepines / toxicity
Thiazines / chemical synthesis*
Thiazines / pharmacology
Thiazines / toxicity
Tranquilizing Agents / chemical synthesis

Substances

Anticonvulsants
Central Nervous System Depressants
Thiazepines
Thiazines
Tranquilizing Agents
Hexobarbital
Pentylenetetrazole