Cancer Res. 1987 Nov 1;47(21):5616-9.

Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers.

Tokunaga K, Nakamura Y, Sakata K, Fujimori K, Ohkubo M, Sawada K, Sakiyama S.

Source

Division of Biochemistry, Chiba Cancer Center Research Institute and Hospital, Japan.

Abstract

We have shown that a Mr 37,000 protein whose expression is strongly enhanced in human lung cancer tissues is the subunit of glyceraldehyde-3-phosphate (GAPDH, EC 1.2.1.12). We have isolated a GAPDH complementary DNA from human lung cancer cells and deduced the complete amino acid sequence of the encoded protein. The structure of the lung cancer GAPDH is identical to that of liver GAPDH. In addition, we have found that GAPDH mRNA expression is markedly increased in human lung cancer tissues. These results disclose a molecular basis of increased glycolysis in cancer cells and reveal an important role of energy creating reaction in cancer cell growth.

PMID:: 3664468; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

HighWire Press

Medical

Lung Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Antisense oligodeoxynucleotide of glyceraldehyde-3-phosphate dehydrogenase gene inhibits cell proliferation and induces apoptosis in human cervical carcinoma cell lines. [Antisense Nucleic Acid Drug De...]
Antisense oligodeoxynucleotide of glyceraldehyde-3-phosphate dehydrogenase gene inhibits cell proliferation and induces apoptosis in human cervical carcinoma cell lines.
Kim JW, Kim TE, Kim YK, Kim YW, Kim SJ, Lee JM, Kim IK, Namkoong SE. Antisense Nucleic Acid Drug Dev. 1999 Dec; 9(6):507-13.
Increased glyceraldehyde-3-phosphate dehydrogenase gene expression in human pancreatic adenocarcinoma. [Cancer Res. 1988]
Increased glyceraldehyde-3-phosphate dehydrogenase gene expression in human pancreatic adenocarcinoma.
Schek N, Hall BL, Finn OJ. Cancer Res. 1988 Nov 15; 48(22):6354-9.
Similarity between glyceraldehyde-3-phosphate dehydrogenase and a 37,000-dalton protein which is abundantly expressed in human lung cancers. [Jpn J Cancer Res. 1986]
Similarity between glyceraldehyde-3-phosphate dehydrogenase and a 37,000-dalton protein which is abundantly expressed in human lung cancers.
Ohkubo M, Nakamura Y, Tokunaga K, Sakiyama S. Jpn J Cancer Res. 1986 Jun; 77(6):554-9.
Decreased Hrad6B expression in lung cancer. [Acta Oncol. 2004]
Decreased Hrad6B expression in lung cancer.
Sasaki H, Moriyama S, Nakashima Y, Yukiue H, Fukai I, Fujii Y. Acta Oncol. 2004; 43(6):585-9.
Review Role of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in normal cell function and in cell pathology. [J Cell Biochem. 1997]
Review Role of the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase, in normal cell function and in cell pathology.
Sirover MA. J Cell Biochem. 1997 Aug 1; 66(2):133-40.

See reviews... See all...

Cited by 56 PubMed Central articles

Conjunctival reconstruction with progenitor cell-derived autologous epidermal sheets in rhesus monkey. [PLoS One. 2011]
Conjunctival reconstruction with progenitor cell-derived autologous epidermal sheets in rhesus monkey.
Lu R, Zhang X, Huang D, Huang B, Gao N, Wang Z, Ge J. PLoS One. 2011; 6(11):e25713. Epub 2011 Nov 11.
MALDI profiling of human lung cancer subtypes. [PLoS One. 2009]
MALDI profiling of human lung cancer subtypes.
Gámez-Pozo A, Sánchez-Navarro I, Nistal M, Calvo E, Madero R, Díaz E, Camafeita E, de Castro J, López JA, González-Barón M, et al. PLoS One. 2009 Nov 5; 4(11):e7731. Epub 2009 Nov 5.
Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer. [Cancer Res. 2009]
Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer.
Menon R, Zhang Q, Zhang Y, Fermin D, Bardeesy N, DePinho RA, Lu C, Hanash SM, Omenn GS, States DJ. Cancer Res. 2009 Jan 1; 69(1):300-9.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human ...
Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers.
Cancer Res. 1987 Nov 1 ;47(21):5616-9.

PubMed
Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotic...
Phenotypic suppression of nonsense mutants in yeast by aminoglycoside antibiotics.
Nature. 1979 Jan 11 ;277(5692):148-50.

PubMed
Anticardiolipin antibodies in rheumatoid arthritis.
Anticardiolipin antibodies in rheumatoid arthritis.
Br J Rheumatol. 1987 Oct ;26(5):346-50.

PubMed
Clomipramine and 'drive' in people with anorexia nervosa: an in-patient study.
Clomipramine and 'drive' in people with anorexia nervosa: an in-patient study.
Br J Psychiatry. 1987 Mar ;150:355-8.

PubMed
Right hemisphere involvement in depression: toward a neuropsychological theory o...
Right hemisphere involvement in depression: toward a neuropsychological theory of negative affective experiences.
Biol Psychiatry. 1987 Oct ;22(10):1201-15.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: