Br J Rheumatol. 1987 Oct;26(5):346-50.

Anticardiolipin antibodies in rheumatoid arthritis.

Keane A, Woods R, Dowding V, Roden D, Barry C.

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Department of Rheumatology, Mater Misericordiae Hospital, Dublin.

Abstract

Anticardiolipin antibody (ACA) was present in the sera of 49% of 90 consecutive patients with rheumatoid arthritis (RA). The ACA was absent in 30 control patients with osteoarthritis. C-reactive protein levels equal to or exceeding 7 mg/dl were found in 10 patients all of whom were ACA positive. ACA was present in a larger proportion of rheumatoid factor (RF) positive than of RF negative patients. Male sex and extra-articular manifestations of RA were both more common in ACA positive than ACA negative patients. In the ACA positive group the lupus anticoagulant and VDRL tests were negative. However, a small number of patients had evidence of vascular events.

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