Biochem J. 1987 May 1;243(3):803-8.

Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?

Source

Department of Biochemistry, King's College (KQC), Strand Campus, London, U.K.

Abstract

Free-radical attack upon uric acid generates allantoin [Ames, Cathcart, Schwiers & Hochstein (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 6858-6862]. Methods are described for the accurate measurement of uric acid and allantoin in human body fluids. The concentrations of uric acid and allantoin in human serum and synovial fluid are reported. It is suggested that measurement of changes in allantoin concentration may be a useful index of free-radical reactions taking place in vivo.

PMID:: 3663100; [PubMed - indexed for MEDLINE]
PMCID:: PMC1147928

Free PMC Article

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

ALLANTOIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Measurement of uric acid, ascorbic acid, and related metabolites in biological fluids. [Anal Biochem. 1984]
Measurement of uric acid, ascorbic acid, and related metabolites in biological fluids.
Hatch LL, Sevanian A. Anal Biochem. 1984 May 1; 138(2):324-8.
Hypoxanthine, uric acid and allantoin as indicators of in vivo free radical reactions. Description of a HPLC method and human brain microdialysis data. [Acta Neurochir (Wien). 2000]
Hypoxanthine, uric acid and allantoin as indicators of in vivo free radical reactions. Description of a HPLC method and human brain microdialysis data.
Marklund N, Ostman B, Nalmo L, Persson L, Hillered L. Acta Neurochir (Wien). 2000; 142(10):1135-41; discussion 1141-2.
Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products. [Chem Biol Interact. 1990]
Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products.
Kaur H, Halliwell B. Chem Biol Interact. 1990; 73(2-3):235-47.
Review Towards the physiological function of uric acid. [Free Radic Biol Med. 1993]
Review Towards the physiological function of uric acid.
Becker BF. Free Radic Biol Med. 1993 Jun; 14(6):615-31.
Review Determination of uremic toxins in biofluids: creatinine, creatine, uric acid and xanthines. [J Chromatogr B Biomed Sci Appl...]
Review Determination of uremic toxins in biofluids: creatinine, creatine, uric acid and xanthines.
Kochansky CJ, Strein TG. J Chromatogr B Biomed Sci Appl. 2000 Sep 29; 747(1-2):217-27.

See reviews... See all...

Cited by 13 PubMed Central articles

Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation. [J Biol Chem. 2011]
Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammation.
Meotti FC, Jameson GN, Turner R, Harwood DT, Stockwell S, Rees MD, Thomas SR, Kettle AJ. J Biol Chem. 2011 Apr 15; 286(15):12901-11. Epub 2011 Jan 25.
Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. [Proc Natl Acad Sci U S A. 2011]
Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation.
Denoble AE, Huffman KM, Stabler TV, Kelly SJ, Hershfield MS, McDaniel GE, Coleman RE, Kraus VB. Proc Natl Acad Sci U S A. 2011 Feb 1; 108(5):2088-93. Epub 2011 Jan 18.
Metabolic signatures of exercise in human plasma. [Sci Transl Med. 2010]
Metabolic signatures of exercise in human plasma.
Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, et al. Sci Transl Med. 2010 May 26; 2(33):33ra37.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Measurement of allantoin and uric acid in human body fluids. A potential index o...
Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?
Biochem J. 1987 May 1 ;243(3):803-8.

PubMed
Reliability of the activities of daily living scale and its use in telephone int...
Reliability of the activities of daily living scale and its use in telephone interview.
Arch Phys Med Rehabil. 1987 Oct ;68(10):723-8.

PubMed
From extracellular to intracellular: the establishment of mitochondria and chlor...
From extracellular to intracellular: the establishment of mitochondria and chloroplasts.
Proc R Soc Lond B Biol Sci. 1979 Apr 11 ;204(1155):165-87.

PubMed
Sexual transmission of dengue viruses by Aedes albopictus.
Sexual transmission of dengue viruses by Aedes albopictus.
Am J Trop Med Hyg. 1987 Sep ;37(2):398-402.

PubMed
Early complications after induced first-trimester abortion.
Early complications after induced first-trimester abortion.
Acta Obstet Gynecol Scand. 1987 ;66(3):201-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: