Powerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies

Affiliations

• ¹ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
• ² School of Statistics, Southwestern University of Finance and Economics, Chengdu, China.
• ³ Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
• ⁴ Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.
• ⁵ Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
• ⁶ Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
• ⁷ Department of Medicine, Harvard Medical School, Boston, MA, USA.
• ⁸ Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
• ⁹ University of Kentucky, College of Public Health, Lexington, KY, USA.
• ¹⁰ Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
• ¹¹ Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
• ¹² Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, The University of Texas Rio Grande Valley, Brownsville, TX, USA.
• ¹³ Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
• ¹⁴ Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
• ¹⁵ Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.
• ¹⁶ Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
• ¹⁷ Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
• ¹⁸ Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
• ¹⁹ Framingham Heart Study, National Heart, Lung, and Blood Institute and Boston University, Framingham, MA, USA.
• ²⁰ Department of Internal Medicine, Nephrology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
• ²¹ The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
• ²² Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.
• ²³ GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• ²⁴ Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
• ²⁵ Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
• ²⁶ Division of Cardiology, George Washington School of Medicine and Health Sciences, Washington, DC, USA.
• ²⁷ Department of Epidemiology, International Health Institute, Department of Anthropology, Brown University, Providence, RI, USA.
• ²⁸ Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
• ²⁹ Geriatrics Research and Education Clinical Center, Baltimore VA Medical Center, Baltimore, MD, USA.
• ³⁰ Division of Endocrinology, Diabetes, and Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
• ³¹ Ministry of Health, Government of Samoa, Apia, Samoa.
• ³² Departments of Epidemiology, University of Washington, Seattle, WA, USA.
• ³³ Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA.
• ³⁴ Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
• ³⁵ Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
• ³⁶ Lutia I Puava Ae Mapu I Fagalele, Apia, Samoa.
• ³⁷ Department of Biostatistics, University of Washington, Seattle, WA, USA.
• ³⁸ Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
• ³⁹ Department of Medicine, Boston University School of Medicine, Boston, MA, USA.
• ⁴⁰ Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
• ⁴¹ Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
• ⁴² Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA.
• ⁴³ Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
• ⁴⁴ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. li@hsph.harvard.edu.
• ⁴⁵ Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, USA. li@hsph.harvard.edu.
• ⁴⁶ Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. xlin@hsph.harvard.edu.
• ⁴⁷ Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA. xlin@hsph.harvard.edu.
• ⁴⁸ Department of Statistics, Harvard University, Cambridge, MA, USA. xlin@hsph.harvard.edu.