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Blood-cerebrospinal fluid barrier in schizophrenic patients.

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  • 1Department of Neurology, University of Ulm, Federal Republic of Germany.

Abstract

A total of 15 young white male patients newly diagnosed as schizophrenic (DMS III) were examined for signs of blood-cerebrospinal fluid (CSF) barrier alteration and CNS IgG synthesis. Of the 15 patients, 8 exhibited signs of increased blood-CSF barrier permeability. There was a high correlation between the ratio for CSF/serum albumin concentration and the CSF total protein concentration. Local IgG synthesis in the CNS was not detected in any of the patients.

PMID:
3653145
[PubMed - indexed for MEDLINE]
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