Alzheimer's-related brain damage shows sex-specific links with risk factors

PLoS Biol. 2022 Dec 14;20(12):e3001905. doi: 10.1371/journal.pbio.3001905. eCollection 2022 Dec.

Abstract

Alzheimer's disease is marked by brain damage from tau and amyloid aggregates, particularly to the hippocampus and the default network. A new study in PLOS Biology shows sex differences in the patterns of damage and in their association with risk and protective factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Alleles
  • Alzheimer Disease* / etiology
  • Apolipoproteins E
  • Brain / metabolism
  • Brain Injuries*
  • Female
  • Humans
  • Male
  • Risk Factors
  • Sex Characteristics
  • tau Proteins / metabolism

Substances

  • tau Proteins
  • Apolipoproteins E