Macronutrient intake: Hormonal controls, pathological states, and methodological considerations

Johnathan T Przybysz; Adrianne M DiBrog; Katherine A Kern; Ashmita Mukherjee; Jason E Japa; Mariana H Waite; Elizabeth G Mietlicki-Baase

doi:10.1016/j.appet.2022.106365

Macronutrient intake: Hormonal controls, pathological states, and methodological considerations

Appetite. 2023 Jan 1:180:106365. doi: 10.1016/j.appet.2022.106365. Epub 2022 Nov 5.

Authors

Johnathan T Przybysz¹, Adrianne M DiBrog¹, Katherine A Kern¹, Ashmita Mukherjee², Jason E Japa³, Mariana H Waite⁴, Elizabeth G Mietlicki-Baase⁵

Affiliations

¹ Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
² Psychology, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
³ Biotechnical and Clinical Laboratory Sciences, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
⁴ Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA.
⁵ Exercise and Nutrition Sciences, School of Public Health and Health Professions, University at Buffalo, State University of New York, Buffalo, NY, 14214, USA; Center for Ingestive Behavior Research, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA. Electronic address: em1@buffalo.edu.

Abstract

A plethora of studies to date has examined the roles of feeding-related peptides in the control of food intake. However, the influence of these peptides on the intake of particular macronutrient constituents of food - carbohydrate, fat, and protein - has not been as extensively addressed in the literature. Here, the roles of several feeding-related peptides in controlling macronutrient intake are reviewed. Next, the relationship between macronutrient intake and diseases including diabetes mellitus, obesity, and eating disorders are examined. Finally, some key considerations in macronutrient intake research are discussed. We hope that this review will shed light onto this underappreciated topic in ingestive behavior research and will help to guide further scientific investigation in this area.

Keywords: Diabetes; Eating disorders; Hormones; Obesity; Sex differences.

Publication types

Review

MeSH terms

Eating*
Humans
Peptides*

Substances

Peptides

Grants and funding

R01 DK128030/DK/NIDDK NIH HHS/United States