Rapid 3D absolute B₁ ⁺ mapping using a sandwiched train presaturated TurboFLASH sequence at 7 T for the brain and heart

Purpose: To shorten the acquisition time of magnetization-prepared absolute transmit field (B₁ ⁺ ) mapping known as presaturation TurboFLASH, or satTFL, to enable single breath-hold whole-heart 3D B₁ ⁺ mapping.

Methods: SatTFL is modified to remove the delay between the reference and prepared images (typically 5 T₁ ), with matching transmit configurations for excitation and preparation RF pulses. The new method, called Sandwich, is evaluated as a 3D sequence, measuring whole-brain and gated whole-heart B₁ ⁺ maps in a single breath-hold. We evaluate the sensitivity to B₁ ⁺ and T₁ using numerical Bloch, extended phase graph, and Monte Carlo simulations. Phantom and in vivo images were acquired in both the brain and heart using an 8-channel transmit 7 Tesla MRI system to support the simulations. A segmented satTFL with a short readout train was used as a reference.

Results: The method significantly reduces acquisition times of 3D measurements from 360 s to 20 s, in the brain, while simultaneously reducing bias in the measured B₁ ⁺ due to T₁ and magnetization history. The mean coefficient of variation was reduced by 81% for T₁ s of 0.5-3 s compared to conventional satTFL. In vivo, the reproducibility coefficient for flip angles in the range 0-130° was 4.5° for satTFL and 4.7° for our scheme, significantly smaller than for a short TR satTFL sequence, which was 12°. The 3D sequence measured B₁ ⁺ maps of the whole thorax in 26 heartbeats.

Conclusion: Our adaptations enable faster B₁ ⁺ mapping, with minimal T₁ sensitivity and lower sensitivity to magnetization history, enabling single breath-hold whole-heart absolute B₁ ⁺ mapping.