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    Pharmacol Ther. 1987;33(1):163-9.

    Influence of mexiletine on caffeine elimination.

    Joeres R, Klinker H, Heusler H, Epping J, Richter E.

    Abstract

    In an acute experiment in healthy volunteers and in patients under long-term treatment for cardiac arrhythmias, mexiletine inhibits caffeine elimination by about 50%. The clearance of mexiletine is not influenced by caffeine. Some side effects of mexiletine may possibly at least partially be attributable to a retention of caffeine.

    PMID:
    3628469
    [PubMed - indexed for MEDLINE]

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