Pharmacol Biochem Behav. 1987 Jun;27(2):351-3.

Effects of idebenone, a cerebral metabolism activator, on muricidal behavior in rats with raphe lesions.

Abstract

The effects of idebenone, a cerebral metabolism activator, on mouse-killing behavior (muricide) in rats with lesions of the midbrain raphe nuclei were studied. Single administration of idebenone (30 and 100 mg/kg, IP) inhibited the muricidal behavior in the raphe-lesioned rats in a dose-dependent manner. Idebenone also suppressed muricide in the olfactory bulbectomized rats, although the effect was less marked than that shown in the raphe-lesioned rats. In addition, the antimuricidal effect of idebenone was augmented with repeated administration. These results support previous findings that idebenone has an activating action on central serotonergic neurons in rats and in patients with cerebrovascular dementia, and suggest that idebenone may improve some of the depressive symptoms often observed in patients with cerebrovascular lesions and other forms of brain disturbance.

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Effects of idebenone, a cerebral metabolism activator, on muricidal behavior in ...
Effects of idebenone, a cerebral metabolism activator, on muricidal behavior in rats with raphe lesions.
Pharmacol Biochem Behav. 1987 Jun ;27(2):351-3.

PubMed
Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in...
Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats.
Jpn J Pharmacol. 1984 Nov ;36(3):349-56.

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Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochon...
Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of the inhibition.
Biochem Biophys Res Commun. 1984 Dec 28 ;125(3):1046-52.

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[Effects of 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone (CV-261...
[Effects of 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone (CV-2619) on adriamycin-induced ECG abnormalities and myocardial energy metabolism in spontaneously hypertensive rats].
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[Effects of idebenone (CV-2619) on neurological deficits, local cerebral blood f...
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Effects of idebenone, a cerebral metabolism activator, on muricidal behavior in rats with raphe lesions.

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