PITTching in for lysosome repair

Claire S Goul; Roberto Zoncu

doi:10.1016/j.devcel.2022.09.014

PITTching in for lysosome repair

Dev Cell. 2022 Oct 24;57(20):2347-2349. doi: 10.1016/j.devcel.2022.09.014.

Authors

Claire S Goul¹, Roberto Zoncu²

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: rzoncu@berkeley.edu.

PMID: 36283389
DOI: 10.1016/j.devcel.2022.09.014

Abstract

Lysosomes, guardians of cell health, can sustain physical damage from biological, mechanical, and chemical stressors, necessitating dedicated mechanisms for their upkeep. In a recent issue of Nature, Tan and Finkel report the discovery of a lysosomal repair pathway controlled by phosphoinositides, which operates via bulk transport of lipids across ER-lysosome contacts.

MeSH terms

Endoplasmic Reticulum* / metabolism
Lipid Metabolism*
Lysosomes* / metabolism
Phosphatidylinositols* / metabolism

Substances

Phosphatidylinositols