Study on swelling, compression property and degradation stability of PVA composite hydrogels for artificial nucleus pulposus

Dingding Xiang; Yangyang Cui; Zhiping Wan; Song Wang; Lu Peng; Zhenhua Liao; Changsheng Chen; Weiqiang Liu

doi:10.1016/j.jmbbm.2022.105496

Study on swelling, compression property and degradation stability of PVA composite hydrogels for artificial nucleus pulposus

J Mech Behav Biomed Mater. 2022 Dec:136:105496. doi: 10.1016/j.jmbbm.2022.105496. Epub 2022 Oct 12.

Authors

Dingding Xiang¹, Yangyang Cui², Zhiping Wan³, Song Wang⁴, Lu Peng⁵, Zhenhua Liao⁴, Changsheng Chen⁶, Weiqiang Liu⁷

Affiliations

¹ School of Mechanical Engineering and Automation, Northeastern University, Shenyang, 110057, China; State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China; Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian, 116081, China. Electronic address: xiangdd@mail.neu.edu.cn.
² State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China; Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; Key Laboratory of Biomedical Materials and Implant Devices, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China.
³ Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
⁴ Key Laboratory of Biomedical Materials and Implant Devices, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China.
⁵ Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; Key Laboratory of Biomedical Materials and Implant Devices, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China.
⁶ Key Laboratory of Biomedical Materials and Implant Devices, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China. Electronic address: ccshbxn@163.com.
⁷ State Key Laboratory of Tribology, Department of Mechanical Engineering, Tsinghua University, Beijing, 100084, China; Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; Key Laboratory of Biomedical Materials and Implant Devices, Research Institute of Tsinghua University in Shenzhen, Shenzhen, 518057, China. Electronic address: weiqliu@hotmail.com.

PMID: 36283297
DOI: 10.1016/j.jmbbm.2022.105496

Abstract

Artificial nucleus pulposus (ANP) replacement as an alternative to the treatment of cervical spondylosis aims to relieve pain and restore the normal cervical motion. In this study, the PVA/PVP and PVA/Pectin composite hydrogels (CH)s with different concentrations were prepared by the freezing-thawing process, and their performances were tested. The effect of different concentrations on both kinds of PVA CHs were evaluated and analysed. The results demonstrated that both kinds of CHs had good swelling property (¿190%), compressive stress-strain characteristic response and stable performance, and they were not easy to degrade (¡9%). The elastic modulus of the PVA/PVP CH was close to that of nucleus pulposus prosthesis, and the weight loss ratio of the PVA/PVP CH was lower than that of PVA/Pectin CH under load condition. Further, the experimental results showed that the PVA/PVP CH with 15 wt% solute and 1 wt% PVP content had the best comprehensive performance, which may provide significant advantages for use in future clinical application in replacing nucleus pulposus.

Keywords: Artificial nucleus pulposus; Composite hydrogel; PVA; PVP; Property.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Elastic Modulus
Hydrogels*
Nucleus Pulposus*
Pectins
Polyvinyl Alcohol

Substances

Hydrogels
Polyvinyl Alcohol
Pectins