Mol Gen Genet. 1978 Sep 20;165(1):21-30.

Correlation between the serine sensitivity and the derepressibility of the ilv genes in Escherichia coli relA- mutants.

Abstract

Upon addition of excess one carbon metabolites (including serine)bacteria stop growing because of isoleucine starvation. After such treatment stringent bacteria rapidly resume normal growth whereas relaxed mutants remain unable for some time to grow. We show here that this is due to a lack of derepressibility of ilv genes after the starvation period. Results are also presented which show that RNA polymerase structural mutants may be selected among the clones resistant to a mixture of serine, methionine and glycine, in relA- strains. Finally circumstancial evidence suggests that the one carbon metabolism may be involved in a process controlling isoleucine metabolism.

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Role for free isoleucine of glycyl-leucine in the repression of threonine deaminase in Escherichia coli. [J Bacteriol. 1974]
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[Gene relA function in the expression of amino acid operons. II. Effect of the allelic state of gene relA on the overproduction of threonine by an Escherichia coli K-12 mutant resistant to beta-hydroxynorvaline]. [Genetika. 1978]
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