Current best practice for bladder cancer: a narrative review of diagnostics and treatments

Eva Compérat; Mahul B Amin; Richard Cathomas; Ananya Choudhury; Maria De Santis; Ashish Kamat; Arnulf Stenzl; Harriet C Thoeny; Johannes Alfred Witjes

doi:10.1016/S0140-6736(22)01188-6

Current best practice for bladder cancer: a narrative review of diagnostics and treatments

Lancet. 2022 Nov 12;400(10364):1712-1721. doi: 10.1016/S0140-6736(22)01188-6. Epub 2022 Sep 26.

Authors

Eva Compérat¹, Mahul B Amin², Richard Cathomas³, Ananya Choudhury⁴, Maria De Santis⁵, Ashish Kamat⁶, Arnulf Stenzl⁷, Harriet C Thoeny⁸, Johannes Alfred Witjes⁹

Affiliations

¹ Department of Pathology, Tenon Hospital, Sorbonne University, Paris, France; Department of Pathology, Medical University of Vienna, Vienna, Austria. Electronic address: evacomperat@gmail.com.
² Department of Pathology and Laboratory Medicine and Urology, University of Tennessee Health Science, Memphis, TN, USA.
³ Department of Oncology/Hematology, Kantonsspital Graubünden, Chur, Switzerland.
⁴ Department of Clinical Oncology, The Christie NHS Foundation Trust and University of Manchester, Manchester, UK.
⁵ Department of Urology, Charité University Hospital, Berlin, Germany.
⁶ Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁷ Department of Urology, University Hospital, Tübingen, Germany.
⁸ Department of Radiology, HFR Fribourg-Hôpital Cantonal, University of Fribourg, Villars-sur-Glâne, Switzerland; Department of Urology, Inselspital University Hospital, Bern, Switzerland.
⁹ Department of Urology, Radboud University Medical Center, Nijmegen, Netherlands.

PMID: 36174585
DOI: 10.1016/S0140-6736(22)01188-6

Abstract

This Seminar presents the current best practice for the diagnosis and management of bladder cancer. The scope of this Seminar ranges from current challenges in pathology, such as the evolving histological and molecular classification of disease, to advances in personalised medicine and novel imaging approaches. We discuss the current role of radiotherapy, surgical management of non-muscle-invasive and muscle-invasive disease, highlight the challenges of treatment of metastatic bladder cancer, and discuss the latest developments in systemic therapy. This Seminar is intended to provide physicians with knowledge of current issues in bladder cancer.

Publication types

Review

MeSH terms

Humans
Neoplasm Invasiveness
Urinary Bladder Neoplasms* / diagnosis
Urinary Bladder Neoplasms* / pathology
Urinary Bladder Neoplasms* / therapy