The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese

Zongbo Zhao; Jianzhong Xue; Ziliang Zhuo; Wei Zhong; Hui Liu

doi:10.2147/NDT.S376066

The Association of IL7R rs6897932 with Risk of Multiple Sclerosis in Southern Chinese

Neuropsychiatr Dis Treat. 2022 Aug 26:18:1855-1859. doi: 10.2147/NDT.S376066. eCollection 2022.

Authors

Zongbo Zhao^#¹, Jianzhong Xue^#¹, Ziliang Zhuo¹, Wei Zhong¹, Hui Liu¹

Affiliation

¹ Department of Neurology and Institute of Neurology, The Affiliated Changshu Hospital of Xuzhou Medical University, Suchow, People's Republic of China.

^# Contributed equally.

Abstract

Objective: To investigate the association between IL7R rs6897932 and multiple sclerosis (MS) in southern Chinese people.

Methods: In total, 147 MS patients and 530 healthy controls were recruited according to the revised McDonald criteria. The TaqMan method was used for genotyping.

Results: With genetic models, we can observe that the additive model, the dominant model, and the recessive model of IL7R rs6897932 were significantly associated with MS [additive model: p=0.032; dominant model (adjusted): p<0.001, OR=3.61 (95% CI 2.25-5.83); recessive model (adjusted): p<0.001, OR=6.80 (95% CI 3.49-13.89)].

Conclusion: Our results suggest that IL7R rs6897932 is associated with MS in a southern Chinese population. More and larger MS studies to explore the genetic risk factors of MS are warranted.

Keywords: IL7R; interleukin; multiple sclerosis; single-nucleotide polymorphism.

Grants and funding

This work was supported by grants from the Project of Key Laboratory of Jiangsu Province [XZSYSKF2020013] and Science and Technology Development Project of Suchow [SKJY2021009]. Funds were used in data collection, data analysis and interpretation, and publication.