Psychol Med. 1987 May;17(2):381-5.

Lymphocyte numbers in endogenous depression.

Murphy D, Gardner R, Greden JF, Carroll BJ.

Abstract

The blood counts of 80 patients with depression were examined (50 unipolar, 30 bipolar). Many had reduced numbers of circulating lymphocytes. This abnormality was more common in the unipolar group (52%) than in the bipolar group (27%). When those patients with an abnormal dexamethasone suppression test response in both groups were compared, the relative and absolute lymphocyte counts were significantly lower in unipolars. Although cortisol hypersecretion may reduce lymphocyte numbers it is not yet clear whether the findings can be satisfactorily explained in this way.

PMID:: 3602230; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

MH 28294/MH/NIMH NIH HHS/United States

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Related citations

Stress lymphocytes and the dexamethasone suppression test in major depressive disorders. [Biol Psychiatry. 1989]
Stress lymphocytes and the dexamethasone suppression test in major depressive disorders.
Miyauchi K, Hirata-Hibi M, Hashimoto M, Hosokawa K. Biol Psychiatry. 1989 Apr 15; 25(8):1021-8.
Depression, cortisol metabolism and lymphocytopenia. [J Affect Disord. 1985]
Depression, cortisol metabolism and lymphocytopenia.
Kronfol Z, Nasrallah HA, Chapman S, House JD. J Affect Disord. 1985 Sep; 9(2):169-73.
Nonsuppression of cortisol in depression and immune function. [Prog Neuropsychopharmacol Biol Psychiatry. ...]
Nonsuppression of cortisol in depression and immune function.
Syvälahti E, Eskola J, Ruuskanen O, Laine T. Prog Neuropsychopharmacol Biol Psychiatry. 1985; 9(4):413-22.
Review The dexamethasone suppression test in patients with mood disorders. [J Clin Psychiatry. 1996]
Review The dexamethasone suppression test in patients with mood disorders.
Rush AJ, Giles DE, Schlesser MA, Orsulak PJ, Parker CR Jr, Weissenburger JE, Crowley GT, Khatami M, Vasavada N. J Clin Psychiatry. 1996 Oct; 57(10):470-84.
Review [Low-dose (0.5 mg) DST in manic and major depressive episodes: in relation to the severity of symptoms]. [Seishin Shinkeigaku Zasshi. 2000]
Review [Low-dose (0.5 mg) DST in manic and major depressive episodes: in relation to the severity of symptoms].
Matsunaga H, Sarai M. Seishin Shinkeigaku Zasshi. 2000; 102(4):367-98.

See reviews... See all...

Cited by 1 PubMed Central article

Review Future directions for brain, behavior, and the immune system. [Bull N Y Acad Med. 1992]
Review Future directions for brain, behavior, and the immune system.
Stein M. Bull N Y Acad Med. 1992 Jul; 68(3):390-410.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Lymphocyte numbers in endogenous depression.
Lymphocyte numbers in endogenous depression.
Psychol Med. 1987 May ;17(2):381-5.

PubMed
Dietary fluoride intake of 15-19-year-old male adults residing in the United Sta...
Dietary fluoride intake of 15-19-year-old male adults residing in the United States.
J Dent Res. 1985 Nov ;64(11):1302-5.

PubMed
Irrigating solutions for arthroscopy. A metabolic study.
Irrigating solutions for arthroscopy. A metabolic study.
J Bone Joint Surg Am. 1983 Jun ;65(5):629-31.

PubMed
Expression of cytokine/growth factors and their receptors in human melanoma and ...
Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes.
Int J Cancer. 1994 Mar 15 ;56(6):853-7.

PubMed
Natural history of HIV-1 cell-free viremia.
Natural history of HIV-1 cell-free viremia.
JAMA. 1995 Aug 16 ;274(7):554-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: