Clinical expression of microRNA-144-5p and its regulatory effect on renal function in uremia

Objective: The study commits to probing the clinical expression of microRNA-144-5p (miR-144-5p) and its modulatory effect on the renal function of uremia.

Methods: Levels of blood urea nitrogen (BUN), β2-microglobulin (β2-MG), serum creatinine (Scr), blood calcium (Ca), phosphorus (P), and intact parathyroid hormone (iPTH) and miR-144-5p expression in serum of uremia patients were detected. The correlation among miR-144-5p expression with BUN, β2-MG, Scr, Ca, P, and iPTH levels in uremic patients was analyzed. The rats were injected with miR-144-5p agomir to detect the change of BUN, Scr, β2-MG, Scr, Ca, P, and iPTH levels in uremic rats.

Results: miR-144-5p expression in uremic patients was negatively correlated with BUN, Scr, β2-MG, P, and iPTH levels, and positively correlated with free Ca concentration in blood. miR-144-5p elevation reduced BUN, Scr, β2-MG, P, and iPTH levels, and increased free Ca concentration in blood in uremic rats.

Conclusion: miR-144-5p is lowly expressed, and miR-144-5p has a regulatory effect on renal function in uremia.