Central cholinergic systems and the P3 evoked potential

Int J Neurosci. 1987 Apr;33(3-4):199-205. doi: 10.3109/00207458708987404.

Abstract

A cognitive evoked potential, the P3, is commonly altered in dementia states but little is known of the specific neuronal generators that are the source of this potential. Event-related evoked potentials and neuropsychological testing were obtained in six normal subjects during neuropharmacological manipulation of the central cholinergic system. Scopolamine (an anticholinergic) impaired recent memory, prolonged P3 latency and decreased P3 amplitude. These abnormalities were partially reversed by physostigmine (an anticholinesterase). The results imply that the cholinergic system is involved in the generation of the P3 potential.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Brain / drug effects
  • Brain / physiology*
  • Cholinergic Fibers / physiology
  • Evoked Potentials* / drug effects
  • Female
  • Humans
  • Male
  • Memory / drug effects
  • Memory / physiology*
  • Physostigmine / pharmacology
  • Reaction Time / drug effects
  • Scopolamine / pharmacology

Substances

  • Physostigmine
  • Scopolamine