Clin Chem. 1987 Jun;33(6):819-20.

Detection of interference by cyclobenzaprine in liquid-chromatographic assays of tricyclic antidepressants.

Abstract

We evaluated a technique for detecting cyclobenzaprine interference with liquid-chromatographic assays for tricyclic antidepressants. The technique involves dual-wavelength absorbance monitoring of the column effluent at 214 and 254 nm. Ratios of analyte peak heights at each wavelength are used to check for the presence of co-eluting interferences. With this technique, one can detect interference with an amitriptyline assay caused by 10 micrograms of cyclobenzaprine per liter.

PMID:: 3594825; [PubMed - indexed for MEDLINE]

Free full text

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

AMITRIPTYLINE - HSDB

Supplemental Content

Related citations

Review Effect of cyclobenzaprine on tricyclic antidepressant assays. [Ann Pharmacother. 2005]
Review Effect of cyclobenzaprine on tricyclic antidepressant assays.
Van Hoey NM. Ann Pharmacother. 2005 Jul-Aug; 39(7-8):1314-7. Epub 2005 Jun 14.
Potential interference of cyclobenzaprine and norcyclobenzaprine with HPLC measurement of amitriptyline and nortriptyline: resolution by GC-MS analysis. [J Anal Toxicol. 1995]
Potential interference of cyclobenzaprine and norcyclobenzaprine with HPLC measurement of amitriptyline and nortriptyline: resolution by GC-MS analysis.
Wong EC, Koenig J, Turk J. J Anal Toxicol. 1995 Jul-Aug; 19(4):218-24.
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond. [Clin J Pain. 2001]
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond.
Lofland JH, Szarlej D, Buttaro T, Shermock S, Jalali S. Clin J Pain. 2001 Mar; 17(1):103-4.
Reversed-phase liquid chromatography and gas chromatography/mass fragmentography compared for determination of tricyclic antidepressant drugs. [Clin Chem. 1981]
Reversed-phase liquid chromatography and gas chromatography/mass fragmentography compared for determination of tricyclic antidepressant drugs.
Breutzmann DA, Bowers LD. Clin Chem. 1981 Nov; 27(11):1907-11.
Review Five-year multicenter retrospective review of cyclobenzaprine toxicity. [J Emerg Med. 1995]
Review Five-year multicenter retrospective review of cyclobenzaprine toxicity.
Spiller HA, Winter ML, Mann KV, Borys DJ, Muir S, Krenzelok EP. J Emerg Med. 1995 Nov-Dec; 13(6):781-5.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

Detection of interference by cyclobenzaprine in liquid-chromatographic assays of...
Detection of interference by cyclobenzaprine in liquid-chromatographic assays of tricyclic antidepressants.
Clin Chem. 1987 Jun ;33(6):819-20.

PubMed
Muscle testing response to provocative vertebral challenge and spinal manipulati...
Muscle testing response to provocative vertebral challenge and spinal manipulation: a randomized controlled trial of construct validity.
J Manipulative Physiol Ther. 1994 Mar-Apr ;17(3):141-8.

PubMed
Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding...
Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase.
J Biol Chem. 1996 Oct 18 ;271(42):26329-34.

PubMed
A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus ...
A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS.
Ann Intern Med. 1991 Nov 1 ;115(9):665-73.

PubMed
Diurnal and seasonal rhythms of melatonin, cortisol and testosterone in interior...
Diurnal and seasonal rhythms of melatonin, cortisol and testosterone in interior Alaska.
Arctic Med Res. 1994 Jan ;53(1):25-34.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

Detection of interference by cyclobenzaprine in liquid-chromatographic assays of tricyclic antidepressants.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Related citations

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information