Neurobiol Aging. 1987 Mar-Apr;8(2):159-65.

Decreased sympathetic innervation of spleen in aged Fischer 344 rats.

Felten SY, Bellinger DL, Collier TJ, Coleman PD, Felten DL.

Abstract

Splenic noradrenergic innervation in young adult and aged Fischer 344 rats was examined using fluorescence histochemistry for catecholamines and high performance liquid chromatography with electrochemical detection (LCEC) for the quantitation of norepinephrine (NE). In young adult rats, abundant noradrenergic plexuses followed the vasculature and trabeculae into splenic white pulp. In aged rats, noradrenergic innervation was reduced in density and in overall intensity of fluorescence, and splenic NE levels were significantly lower. The relationship between diminished noradrenergic innervation and diminished immune responsiveness in aging mammals, while not clear on a causal level, is presented as a hypothesis for further testing.

PMID:: 3587492; [PubMed - indexed for MEDLINE]

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Norepinephrine

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Noradrenergic sympathetic innervation of the spleen: IV. Morphometric analysis in adult and aged F344 rats. [J Neurosci Res. 1987]
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Cited by 4 PubMed Central articles

Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development. [Eur J Immunol. 2011]
Absence of Rac1 and Rac3 GTPases in the nervous system hinders thymic, splenic and immune-competence development.
Basso V, Corbetta S, Gualdoni S, Tonoli D, Poliani PL, Sanvito F, Doglioni C, Mondino A, de Curtis I. Eur J Immunol. 2011 May; 41(5):1410-9. Epub 2011 Apr 15.
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