The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis

Anirban Goutam Mukherjee; Uddesh Ramesh Wanjari; Pragya Bradu; Reshma Murali; Sandra Kannampuzha; Tamizhini Loganathan; George Priya Doss C; Arun Prakash B P; Kaviyarasi Renu; Abhijit Dey; Balachandar Vellingiri; Abilash Valsala Gopalakrishnan

doi:10.1016/j.critrevonc.2022.103757

The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis

Crit Rev Oncol Hematol. 2022 Aug:176:103757. doi: 10.1016/j.critrevonc.2022.103757. Epub 2022 Jul 7.

Affiliations

¹ Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
² Department of Integrative Biology, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India.
³ Department of Genetics, Dr. ALM PG IBMS University of Madras, Taramani, Chennai 600113, India.
⁴ Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600077, Tamil Nadu, India.
⁵ Department of Life Sciences, Presidency University, Kolkata, West Bengal 700073, India.
⁶ Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641046, Tamil Nadu, India.
⁷ Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu 632014, India. Electronic address: abilash.vg@vit.ac.in.

PMID: 35809795
DOI: 10.1016/j.critrevonc.2022.103757

Abstract

The human microbiome's role in colon and breast cancer is described in this review. Understanding how the human microbiome and metabolomics interact with breast and colon cancer is the chief area of this study. First, the role of the gut and distal microbiome in breast and colon cancer is investigated, and the direct relationship between microbial dysbiosis and breast and colon cancer is highlighted. This work also focuses on the many metabolomic techniques used to locate prospective biomarkers, make an accurate diagnosis, and research new therapeutic targets for cancer treatment. This review clarifies the influence of anti-tumor medications on the microbiota and the proactive measures that can be taken to treat cancer using a variety of therapies, including radiotherapy, chemotherapy, next-generation biotherapeutics, gene-based therapy, integrated omics technology, and machine learning.

Keywords: Biotherapeutics; Breast cancer; Colon cancer; Human microbiome; Metabolites; Metabolomics.

Publication types

Review

MeSH terms

Breast Neoplasms* / therapy
Colonic Neoplasms* / diagnosis
Colonic Neoplasms* / therapy
Dysbiosis
Female
Humans
Metabolomics / methods
Microbiota*