Comparison of Waning Neutralizing Antibody Responses Against the Omicron Variant 6 Months After Natural Severe Acute Respiratory Syndrome Coronavirus 2 Infection (With or Without Subsequent Coronavirus Disease 2019 [COVID-19] Vaccination) Versus 2-Dose COVID-19 Vaccination

So Yun Lim; Soonju Park; Ji Yeun Kim; Seungtaek Kim; Youngmee Jee; Sung-Han Kim

doi:10.1093/cid/ciac435

Comparison of Waning Neutralizing Antibody Responses Against the Omicron Variant 6 Months After Natural Severe Acute Respiratory Syndrome Coronavirus 2 Infection (With or Without Subsequent Coronavirus Disease 2019 [COVID-19] Vaccination) Versus 2-Dose COVID-19 Vaccination

Clin Infect Dis. 2022 Dec 19;75(12):2243-2246. doi: 10.1093/cid/ciac435.

Authors

So Yun Lim¹, Soonju Park², Ji Yeun Kim¹, Seungtaek Kim², Youngmee Jee², Sung-Han Kim¹

Affiliations

¹ Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
² Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, Republic of Korea.

Abstract

Following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, subsequent ChAdOx1 nCoV-19 vaccination induced similar neutralizing antibody levels against the original strain but significantly higher levels against the Omicron variant compared to those who were not vaccinated. Prior SARS-CoV-2 infection exhibited higher neutralization antibody titers than vaccination alone for both original strains and the Omicron variant.

Keywords: COVID-19; SARS-CoV-2; antibody response; hybrid immunity; vaccine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing
Antibodies, Viral
COVID-19 Vaccines
COVID-19*
ChAdOx1 nCoV-19
Humans
SARS-CoV-2
Vaccination

Substances

COVID-19 Vaccines
ChAdOx1 nCoV-19
Antibodies, Neutralizing
Antibodies, Viral

Supplementary concepts

SARS-CoV-2 variants