Circ_CDR1as: A circular RNA with roles in the carcinogenesis

Soudeh Ghafouri-Fard; Tayybeh Khoshbakht; Bashdar Mahmud Hussen; Sana Sarfaraz; Mohammad Taheri; Seyed Abdulmajid Ayatollahi

doi:10.1016/j.prp.2022.153968

Circ_CDR1as: A circular RNA with roles in the carcinogenesis

Pathol Res Pract. 2022 Aug:236:153968. doi: 10.1016/j.prp.2022.153968. Epub 2022 Jun 1.

Authors

Soudeh Ghafouri-Fard¹, Tayybeh Khoshbakht², Bashdar Mahmud Hussen³, Sana Sarfaraz⁴, Mohammad Taheri⁵, Seyed Abdulmajid Ayatollahi⁶

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
² Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Iraq.
⁴ Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
⁵ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Institute of Human Genetics, Jena University Hospital, Jena, Germany. Electronic address: mohammad.taheri@uni-jena.de.
⁶ Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pharmacognosy and Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: majid_ayatollahi@sbmu.ac.ir.

PMID: 35667198
DOI: 10.1016/j.prp.2022.153968

Abstract

Circular RNAs are a group of ancient but recently appreciated transcripts that affect carcinogenesis. An example of cancer-related circular RNAs is circ_CDR1as. It is mostly regarded as an oncogenic circular RNA, yet in bladder cancer and glioma it has the opposite effect. In gastric and ovarian cancer, both roles have been reported for this circular RNA. Circ_CDR1as has regulatory effects on miR-1270/AFP, miR-1287/Raf1, miR-7-5p/KLF4, miR-641/HOXA9, miR-219a-5p/SOX5, miR-7/HOXB13 and miR-876-5p/MAGE-A molecular axes. miR-7 is the most appreciated interacting miRNA with circ_CDR1as, since its interaction with circ_CDR1as has been validated in liver cancer, lung cancer, colorectal cancer, esophageal carcinoma, gastric cancer, pancreatic cancer, thyroid cancer, oral squamous cell carcinoma, nasopharyngeal carcinoma and osteosarcoma. The present article aims at summarization of the role of circ_CDR1as in neoplasms and its application as a biomarker in human cancers.

Keywords: Cancer; CircRNA Cdr1as; Expression.

Publication types

Review

MeSH terms

Carcinogenesis / genetics
Carcinoma, Squamous Cell* / pathology
Cell Line, Tumor
Cell Proliferation / genetics
Gene Expression Regulation, Neoplastic
Humans
MicroRNAs* / genetics
Mouth Neoplasms* / genetics
RNA, Circular / genetics

Substances

MIRN1270 microRNA, human
MIRN1287 microRNA, human
MIRN641 microRNA, human
MIRN876 microRNA, human
MicroRNAs
RNA, Circular