Cysts and cyst-like lesions are common occurrences seen in a busy plastic surgical practice. Although many can be treated by surgical excision, they still represent an interesting histologic, etiologic, embryologic, and clinical spectrum. In a number of instances, they require detailed multidiagnostic evaluation and complex surgical approaches to excision. By classifying these cystic masses by age group and anatomic location, the clinician can simplify his or her approach to this group of cutaneous masses.