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Complete amino acid sequence of human serum cholinesterase.
The complete amino acid sequence of human serum cholinesterase (choline esterase II (unspecific), EC 3.1.1.8) was determined by Edman degradation of purified peptides. The protein contains 574 amino acids per subunit and nine carbohydrate chains attached to 9 asparagines. The four subunits of cholinesterase appear to be identical. The active site serine is the 198th residue from the amino terminus. The sequence of human serum cholinesterase is 53.8% identical with the sequence of acetylcholinesterase from Torpedo californica and 28% identical with the carboxyl-terminal portion of bovine thyroglobulin.
PMID: 3542989 [PubMed - indexed for MEDLINE]
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Cited by 37 PubMed Central articles
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Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin.
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BMC Biotechnol. 2008 May 16; 8:50. Epub 2008 May 16.
[BMC Biotechnol. 2008]
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Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning.
Huang YJ, Huang Y, Baldassarre H, Wang B, Lazaris A, Leduc M, Bilodeau AS, Bellemare A, Côté M, Herskovits P, et al.
Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13603-8. Epub 2007 Jul 27.
[Proc Natl Acad Sci U S A. 2007]
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LARGE SCALE PURIFICATION OF BUTYRYLCHOLINESTERASE FROM HUMAN PLASMA SUITABLE FOR INJECTION INTO MONKEYS; A POTENTIAL NEW THERAPEUTIC FOR PROTECTION AGAINST COCAINE AND NERVE AGENT TOXICITY.
Lockridge O, Schopfer LM, Winger G, Woods JH.
J Med Chem Biol Radiol Def. 2005 Jul 1; 3:nihms5095.
[J Med Chem Biol Radiol Def. 2005]
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