A Tale of Two Histologies: Dissecting the Biology of Lineage Transformation in Lung Cancer

Cancer Discov. 2021 Dec 1;11(12):2962-2964. doi: 10.1158/2159-8290.CD-21-1222.

Abstract

Lineage plasticity is an important, and likely underappreciated, mechanism of treatment resistance in lung cancer. Here, Quintanal-Villalonga and colleagues integrate results from multiomic analyses to provide key new insights into the biology of lineage plasticity. See related article by Quintanal-Villalonga et al., p. 3028.

Publication types

  • Editorial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Biology
  • Humans
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / genetics