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A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas.
Deposition of amyloid is the most constantly present alteration in the islets of Langerhans in type 2 diabetes mellitus and is also quite common in insulin-producing tumors of the pancreas and it is very likely that these two amyloids are identical. We have isolated amyloid fibrils from an insulin-secreting human tumour and purified the fibrillar protein. N-terminal amino acid sequence of the protein is unique and does not resemble insulin or its precursors. Instead it has about 50% homology with the neuropeptide CGRP (calcitonin gene related peptide).
PMID: 3535798 [PubMed - indexed for MEDLINE]
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Cited by 24 PubMed Central articles
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ReviewAmyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure.
Andersson A, Bohman S, Borg LA, Paulsson JF, Schultz SW, Westermark GT, Westermark P.
Exp Diabetes Res. 2008; 2008:562985. Epub 2009 Mar 5.
[Exp Diabetes Res. 2008]
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The role of the 14-20 domain of the islet amyloid polypeptide in amyloid formation.
Gilead S, Gazit E.
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[Exp Diabetes Res. 2008]
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RNA interference of achaete-scute homolog 1 in mouse prostate neuroendocrine cells reveals its gene targets and DNA binding sites.
Hu Y, Wang T, Stormo GD, Gordon JI.
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[Proc Natl Acad Sci U S A. 2004]
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