Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends

Michel Sabe; Toby Pillinger; Stefan Kaiser; Chaomei Chen; Heidi Taipale; Antti Tanskanen; Jari Tiihonen; Stefan Leucht; Christoph U Correll; Marco Solmi

doi:10.1016/j.neubiorev.2022.104608

Half a century of research on antipsychotics and schizophrenia: A scientometric study of hotspots, nodes, bursts, and trends

Neurosci Biobehav Rev. 2022 May:136:104608. doi: 10.1016/j.neubiorev.2022.104608. Epub 2022 Mar 15.

Authors

Affiliations

¹ Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, 2, Chemin du Petit-Bel-Air, CH-1226 Thonex, Switzerland. Electronic address: michel.sabe@hcuge.ch.
² Institute of Psychiatry, Psychology and Neuroscience, Department of Psychosis Studies, King's College of London, London, UK; Psychiatric Imaging Group, MRC London Institute of Medical Sciences, Hammersmith Hospital, Imperial College London, London, UK; Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
³ Division of Adult Psychiatry, Department of Psychiatry, University Hospitals of Geneva, 2, Chemin du Petit-Bel-Air, CH-1226 Thonex, Switzerland.
⁴ College of Computing & Informatics, Drexel University, Philadelphia, PA, USA.
⁵ Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; University of Eastern Finland, School of Pharmacy, Kuopio, Finland; Department of Clinical Neuroscience, Karolinska Institutet and Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden.
⁶ Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; Department of Clinical Neuroscience, Karolinska Institutet and Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden.
⁷ Department of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland; Department of Clinical Neuroscience, Karolinska Institutet and Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden; Neuroscience Center, University of Helsinki, Helsinki, Finland.
⁸ Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
⁹ Department of Psychiatry Research, The Zucker Hillside Hospital, Glen Oaks, NY, USA; Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.
¹⁰ Department of Psychiatry, University of Ottawa, Ontario, Canada; Department of Mental Health, The Ottawa Hospital, Ontario, Canada; Ottawa Hospital Research Institute (OHRI) Clinical Epidemiology Program University of Ottawa, Ontario, Ottawa.

PMID: 35303594
DOI: 10.1016/j.neubiorev.2022.104608

Abstract

Changes over 50 years of research on antipsychotics in schizophrenia have occurred. A scientometric synthesis of such changes over time and a measure of researchers' networks and scientific productivity is currently lacking. We searched Web of Science Core Collection from inception until November 5, 2021, using the appropriate key. Our primary objective was to conduct systematic mapping with CiteSpace to show how clusters of keywords have evolved over time and obtain clusters' structure and credibility. Our secondary objective was to measure research network performance (countries, institutions, and authors) using CiteSpace, VOSviewer, and Bibliometrix. We included 32,240 studies published between 1955 and 2021. The co-cited reference network identified 25 clusters with a well-structured network (Q=0.8166) and highly credible clustering (S=0.91). The main trends of research were: 1) antipsychotic efficacy; 2) cognition in schizophrenia; 3) side effects of antipsychotics. Last five years research trends were: 'ultra-resistance schizophrenia' (S=0.925), 'efficacy/dose-response' (S=0.775), 'evidence-synthesis' (S=0.737), 'real-world effectiveness' (S=0.794), 'cannabidiol' (S=0.989), and 'gut microbiome' (S=0.842). These results can inform funding agencies and research groups' future directions.

Keywords: CiteSpace; Evidence synthesis; Meta-analysis; Psychosis; Scientometric; Systematic review.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antipsychotic Agents* / therapeutic use
Humans
Publications
Schizophrenia* / drug therapy

Substances

Antipsychotic Agents

Grants and funding

DH_/Department of Health/United Kingdom