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Biull Eksp Biol Med. 1986 Jun;101(6):717-9.

[Differentiation potentials of clonal strains of bone marrow fibroblasts].

[Article in Russian]


The clonal nature of CFUf-derived fibroblast colonies was proved by chromosomal analysis of individual colonies and single-colony-derived fibroblast strains using mixed cell cultures from male and female rabbits. CFUf progeny, forming colonies composed of more than 10(3) cells was capable of 20-30 cell doublings during subsequent passages. When transplanted in diffusion chambers, single-colony-derived fibroblast strains formed bone and cartilage simultaneously. Thus, CFUf or part of them can be regarded as bone marrow osteogenic stem cells.

[PubMed - indexed for MEDLINE]
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