[New eudesmane sesquiterpenoids from Atractylodis Macrocephalae Rhizoma and their inhibitory activities against SREBPs]

Zhongguo Zhong Yao Za Zhi. 2022 Jan;47(2):428-432. doi: 10.19540/j.cnki.cjcmm.20211014.201.
[Article in Chinese]

Abstract

Three sesquiterpenoids were isolated and purified from the 95% ethanol extract of Atractylodis Macrocephalae Rhizoma by column chromatography on silica gel, Sephadex LH-20, ODS, and high-performance liquid chromatography(HPLC). Their chemical structures were identified on the basis of spectroscopic analysis and physiochemical properties as(7Z)-8β,13-diacetoxy-eudesma-4(15),7(11)-diene(1), 7-oxo-7,8-secoeudesma-4(15),11-dien-8-oic acid(2), and guai-10(14)-en-11-ol(3). Compounds 1 and 2 are new compounds and compound 3 was obtained from Compositae family for the first time. Compounds 1, 2, and 3 showed weak inhibitory activities against sterol regulatory element-binding proteins(SREBPs).

Keywords: Atractylodis Macrocephalae Rhizoma; SREBPs inhibitor; chemical constituent; sesquiterpenoid.

MeSH terms

  • Atractylodes* / chemistry
  • Drugs, Chinese Herbal* / chemistry
  • Rhizome / chemistry
  • Sesquiterpenes, Eudesmane* / analysis
  • Sesquiterpenes, Eudesmane* / pharmacology
  • Sterol Regulatory Element Binding Proteins / antagonists & inhibitors*

Substances

  • Drugs, Chinese Herbal
  • Sesquiterpenes, Eudesmane
  • Sterol Regulatory Element Binding Proteins