Triple negative breast cancer (TNBC) is prone to recurrence and metastasis, which is the subtype of poorest prognosis. Chemotherapy is the main treatment, although there is lack of effective adjuvant chemotherapy regimens. The unsatisfactory efficacy of chemotherapy has been a bottleneck in improving the outcome of TNBC. Platinum compounds act directly on DNA to kill tumor cells, and they have a stronger killing effect on tumor cells carrying DNA damage repair (DDR) defects, which is an important entry point to improve the efficacy of TNBC. Biomarkers for predicting the efficacy of platinum drugs in TNBC treatment have always been a hot topic. The DDR pathway contains a large number of related genes, and recent studies have shown that deficiencies in the DDR pathway may be associated with the efficacy of platinum drugs, which is expected to be a biomarker for predicting the efficacy of platinum drugs in breast cancer treatment.
三阴性乳腺癌(TNBC)极易复发和远处转移，是预后最差的乳腺癌亚型，其主要的治疗手段为化疗，但目前仍缺乏有效的辅助化疗方案。化疗效果不理想成为阻碍TNBC疗效提高的瓶颈问题。铂类药物作用于细胞DNA，通过损伤肿瘤细胞DNA，达到杀灭肿瘤的作用，对携带DNA损伤修复缺陷的肿瘤细胞有更强的杀伤作用，成为提高TNBC疗效的重要切入点。寻找能够预测铂类药物在TNBC治疗疗效的生物标志物始终为热点问题之一。DNA损伤修复(DDR)通路包含大量相关基因，DDR通路功能缺失可能与铂类药物疗效相关，其有望成为预测铂类药物治疗乳腺癌疗效的生物标志物。.
Keywords: Breast neoplasms; DNA damage repair; Platinum; Triple negative breast cancer.