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Epilepsy Res. 1987 Jul;1(4):262-4.

Induction of seizures by air blast in gerbils: stimulus duration/effect relationship.

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  • 1Laboratory of Pharmacology and Toxicology, School of Veterinary Medicine, Free University of Berlin, F.R.G.


In air blast-induced seizures in gerbils, there is a relationship between the duration of the air blast and the incidence of 'major' convulsions. An ET50 of 9.6 sec was determined in untreated controls; pretreatment with anticonvulsant drugs shifted the stimulus/effect curve to the right. This 'stimulus summation' phenomenon makes a clearly defined challenge necessary when drug effects are to be evaluated.

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