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Br J Psychiatry. 1987 Dec;151:753-7.

The Copenhagen high-risk project. The diagnosis of maternal schizophrenia and its relation to offspring diagnosis.

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  • 1Psykologisk Institut, Kommunehospitalet, Københaven, Denmark.


The Copenhagen longitudinal high-risk study of offspring of 129 schizophrenic mothers commenced in 1962. At that time, the mothers were diagnosed according to contemporary Danish criteria. We have re-examined all of the hospital records of these mothers: 108 (84%) fulfil present-day DSM-III criteria for schizophrenia and 95 (74%) were diagnosed as paranoid schizophrenic according to ICD-8 criteria. In a follow-up at mean age 24, the offspring of the paranoid schizophrenic mothers were themselves found to be less frequently schizophrenic (5%) than were the offspring of non-paranoid schizophrenic mothers (29%).

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