Targeting Epigenetics and Non-coding RNAs in Myocardial Infarction: From Mechanisms to Therapeutics

Jinhong Chen; Zhichao Liu; Li Ma; Shengwei Gao; Huanjie Fu; Can Wang; Anmin Lu; Baohe Wang; Xufang Gu

doi:10.3389/fgene.2021.780649

Targeting Epigenetics and Non-coding RNAs in Myocardial Infarction: From Mechanisms to Therapeutics

Front Genet. 2021 Dec 20:12:780649. doi: 10.3389/fgene.2021.780649. eCollection 2021.

Authors

Jinhong Chen¹, Zhichao Liu¹, Li Ma¹, Shengwei Gao¹, Huanjie Fu¹, Can Wang², Anmin Lu¹, Baohe Wang³, Xufang Gu³

Affiliations

¹ Department of TCM, Tianjin University of TCM, Tianjin, China.
² Acupuncture Department, The First Affiliated Hospital of Tianjin University of TCM, Tianjin, China.
³ Department of Cardiology, The Second Affiliated Hospital of Tianjin University of TCM, Tianjin, China.

Abstract

Myocardial infarction (MI) is a complicated pathology triggered by numerous environmental and genetic factors. Understanding the effect of epigenetic regulation mechanisms on the cardiovascular disease would advance the field and promote prophylactic methods targeting epigenetic mechanisms. Genetic screening guides individualised MI therapies and surveillance. The present review reported the latest development on the epigenetic regulation of MI in terms of DNA methylation, histone modifications, and microRNA-dependent MI mechanisms and the novel therapies based on epigenetics.

Keywords: DNA methylation DNA; cardiovascular; epigenetics; histone modifications; micro-RNA; myocardial infarction; non-coding RNAs rna.

Publication types

Review