Biophys J. 1987 Feb;51(2):351-5.

Optical recording of action potential propagation in demyelinated frog nerve.

Shrager P, Chiu SY, Ritchie JM, Zecevic D, Cohen LB.

Abstract

Conduction in focally demyelinated frog nerves has been measured optically using potential-sensitive dyes. Absorption changes were recorded with an array of photodiodes positioned in the image plane of a microscope. Both the amplitude and conduction velocity of the optical signals decreased in the demyelinated region. Conduction was improved after exposure to the potassium channel blocking agent 4-aminopyridine.

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PMCID:: PMC1329897

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