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Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.
Wong GG,
Temple PA,
Leary AC,
Witek-Giannotti JS,
Yang YC,
Ciarletta AB,
Chung M,
Murtha P,
Kriz R,
Kaufman RJ, et al.
A 4-kilobase complementary DNA (cDNA) encoding human macrophage-specific colony-stimulating factor (CSF-1) was isolated. When introduced into mammalian cells, this cDNA directs the expression of CSF-1 that is structurally and functionally indistinguishable from the natural human urinary CSF-1. Direct structural analysis of both the recombinant CSF-1 and the purified human urinary protein revealed that these species contain a sequence of at least 40 amino acids at their carboxyl termini which are not found in the coding region of a 1.6-kilobase CSF-1 cDNA that was previously described. These results demonstrate that the human CSF-1 gene can be expressed to yield at least two different messenger RNA species that encode distinct but related forms of CSF-1.
PMID: 3493529 [PubMed - indexed for MEDLINE]
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Cited by 41 PubMed Central articles
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cAMP attenuates interleukin-1-stimulated macrophage colony-stimulating factor (M-CSF) expression.
Kamthong PJ, Wu FM, Wu MC.
Biochem J. 2000 Aug 15; 350 Pt 1:115-22.
[Biochem J. 2000]
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Therapeutic efficacy of human macrophage colony-stimulating factor, used alone and in combination with antifungal agents, in mice with systemic Candida albicans infection.
Kuhara T, Uchida K, Yamaguchi H.
Antimicrob Agents Chemother. 2000 Jan; 44(1):19-23.
[Antimicrob Agents Chemother. 2000]
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The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK.
J Virol. 1998 May; 72(5):4015-21.
[J Virol. 1998]
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