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Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.
Yang YC,
Ciarletta AB,
Temple PA,
Chung MP,
Kovacic S,
Witek-Giannotti JS,
Leary AC,
Kriz R,
Donahue RE,
Wong GG, et al.
A cDNA clone encoding a novel hematopoietic growth factor activity produced by a gibbon T cell line has been identified using a mammalian cell expression cloning system. The sequence of this cDNA proved to have significant homology to the sequence encoding murine interleukin 3 (IL-3). The human gene, which was readily identified because of its high degree of homology to the gibbon sequence, also displayed significant homology with the murine IL-3 sequence. The recombinant gibbon IL-3 protein proved to have multipotent colony stimulating activity when tested with normal human bone marrow cells, proving that this primate hematopoietin is not only structurally but also functionally related to murine IL-3.
PMID: 3489530 [PubMed - indexed for MEDLINE]
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Cited by over 100 PubMed Central articles
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How a cytokine is chaperoned through the secretory pathway by complexing with its own receptor: lessons from interleukin-15 (IL-15)/IL-15 receptor alpha.
Duitman EH, Orinska Z, Bulanova E, Paus R, Bulfone-Paus S.
Mol Cell Biol. 2008 Aug; 28(15):4851-61. Epub 2008 May 27.
[Mol Cell Biol. 2008]
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ReviewHematopoietic cytokines.
Metcalf D.
Blood. 2008 Jan 15; 111(2):485-91.
[Blood. 2008]
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Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells.
Hiraoka A, Sugimura A, Seki T, Nagasawa T, Ohta N, Shimonishi M, Hagiya M, Shimizu S.
Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14):7577-82.
[Proc Natl Acad Sci U S A. 1997]
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