Long-term ambient PM_2.5 exposure associated with cardiovascular risk factors in Chinese less educated population

Introduction: Long-term exposure to ambient air pollution is related to major cardiovascular risk factors including diabetes, hypertension, hyperlipidemia and overweight, but with few studies in high-concentration nations like China so far. We aimed to investigate the association between long-term exposure to ambient fine particulate matter (particles with an aerodynamic diameter ≤ 2.5 μm, PM_2.5) and major cardiovascular risk factors in China.

Methods: Adult participants with selected biochemical tests were recruited from the Chinese Physiological Constant and Health Condition (CPCHC) survey conducted from 2007 to 2011. Gridded PM_2.5 data used were derived from satellite-observed data with adjustment of ground-observed data. District-level PM_2.5 data were generated to estimate the association using multivariate logistic regression model and generalized additive model.

Results: A total of 19,236 participants from the CPCHC survey were included with an average age of 42.8 ± 16.1 years, of which nearly half were male (47.0%). The annual average PM_2.5 exposure before the CPCHC survey was 33.4 (14.8-53.4) μg/m³, ranging from 8.0 μg/m³ (Xiwuqi) to 94.7 μg/m³ (Chengdu). Elevated PM_2.5 was associated with increased prevalence of hypertension (odds ratio (OR) =1.022, 95% confidence interval (95%CI): 1.001, 1.043) and decreased prevalence of overweight (OR = 0.926, 95%CI: 0.910, 0.942). Education significantly interacted with PM_2.5 in association with all the interesting risk factors. Each 10 μg/m³ increment of PM_2.5 was associated with increased prevalence of diabetes (OR = 1.118, 95%CI: 1.037, 1.206), hypertension (OR = 1.101, 95%CI: 1.056, 1.147), overweight (OR = 1.071, 95%CI: 1.030, 1.114) in participants with poor education, but not in well-educated population. PM_2.5 exposure was negatively associated with hyperlipidemia in all participants (OR = 0.939, 95%CI: 0.921, 0.957). The results were robust in all the sensitivity analyses.

Conclusion: Association between long-term PM_2.5 exposure and cardiovascular risk factors might be modified by education. PM_2.5 was associated with a higher prevalence of diabetes, hypertension, and overweight in a less-educated population with time-expose dependency. Long-term exposure to PM_2.5 might be associated with a lower prevalence of hyperlipidemia.